CPK (creatine phosphokinase), also called CK, is an enzyme found in muscles, the heart and the brain. It rises when muscle is damaged.
- Normal range (adults)
- Men 39–308 U/L · Women 26–192 U/L
- Sample
- Blood
- Fasting
- Not usually needed
- Also called
- CK, Creatine Kinase, CPK, CK Total, Creatine Phosphokinase, Total CK
CPK / Creatine Kinase normal range
| Group | U/LSame unit in all countries |
|---|---|
| Men | 39–308 |
| Women | 26–192 |
Ranges vary slightly between laboratories. The range printed on your own report is the one to go by.
Why is the CPK / Creatine Kinase test done?
It is checked for muscle pain or weakness, muscle injury, and in people taking statins who develop muscle aches.
What does a high CPK / Creatine Kinase level mean?
A high CK means muscle breakdown. Mild rises after exercise are common; very high levels (rhabdomyolysis) can damage the kidneys.
Common causes
- Strenuous exercise or gym training in the days before the test
- Muscle injury, falls or injections
- Statin side effects
- Underactive thyroid
- Muscle diseases (myositis, muscular dystrophy)
- Heat stroke or prolonged immobility
Diet and lifestyle tips
- Avoid heavy exercise for 48 to 72 hours before a repeat test
- Drink plenty of water
- Tell your doctor if you take statins and have muscle pain
What does a low CPK / Creatine Kinase level mean?
A low CK usually reflects low muscle mass and is not a concern.
Common causes
- Low muscle mass
- Older age
Diet and lifestyle tips
- Stay active and eat enough protein
When should you see a doctor?
Seek urgent care for severe muscle pain with dark or cola-coloured urine.
Last updated
This page is for general education and is not a diagnosis. Normal ranges differ between laboratories, so always compare your result with the reference range printed on your own report, and discuss abnormal results with your doctor.