SHBG (sex hormone binding globulin) is a protein that binds testosterone and estrogen, controlling how much is available to tissues.
- Normal range (adults)
- Men 10–57 nmol/L · Women 18–144 nmol/L
- Sample
- Blood
- Fasting
- Not usually needed
- Also called
- Sex Hormone Binding Globulin, Sex Hormone-Binding Globulin
SHBG normal range
| Group | nmol/LSame unit in all countries |
|---|---|
| Men | 10–57 |
| Women | 18–144 |
Ranges vary slightly between laboratories. The range printed on your own report is the one to go by.
Why is the SHBG test done?
It helps interpret testosterone results, and is checked in PCOS and insulin resistance.
What does a high SHBG level mean?
High SHBG lowers the free, active testosterone.
Common causes
- Ageing
- Overactive thyroid
- Liver disease
- Estrogen pills or pregnancy
- Low body weight
Diet and lifestyle tips
- Eat enough calories and protein if underweight
What does a low SHBG level mean?
Low SHBG increases free testosterone and is a marker of insulin resistance.
Common causes
- Overweight and insulin resistance
- Type 2 diabetes
- PCOS
- Underactive thyroid
Diet and lifestyle tips
- Cut sugar and refined carbohydrates
- Regular exercise and weight loss
When should you see a doctor?
Interpret with your testosterone results.
Last updated
This page is for general education and is not a diagnosis. Normal ranges differ between laboratories, so always compare your result with the reference range printed on your own report, and discuss abnormal results with your doctor.